Version 5.4
Homo sapiens Protein: AIDA
Summary
InnateDB Protein IDBP-106828.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AIDA
Protein Name axin interactor, dorsalization associated
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000347964
InnateDB Gene IDBG-106820 (AIDA)
Protein Structure
UniProt Annotation
Function Acts as a ventralizing factor during embryogenesis. Inhibits axin-mediated JNK activation by binding axin and disrupting axin homodimerization. This in turn antagonizes a Wnt/beta-catenin-independent dorsalization pathway activated by AXIN/JNK-signaling (By similarity). {ECO:0000250}.
Subcellular Localization
Disease Associations
Tissue Specificity Widely expressed in adult tissues, with highest expression in the heart and skeletal muscle. {ECO:0000269PubMed:17681137}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 5 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0009953 dorsal/ventral pattern formation
GO:0043496 regulation of protein homodimerization activity
GO:0043508 negative regulation of JUN kinase activity
GO:0046329 negative regulation of JNK cascade
Cellular Component
GO:0005575 cellular_component
Protein Structure and Domains
PDB ID
InterPro IPR023421 Axin interactor, dorsalization-associated protein, N-terminal
PFAM PF08910
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96BJ3
PhosphoSite PhosphoSite-Q96BJ3
TrEMBL
UniProt Splice Variant
Entrez Gene 64853
UniGene Hs.743777
RefSeq
HUGO HGNC:25761
OMIM 612375
CCDS
HPRD 07798
IMGT
EMBL AK022868 AK289865 AL392172 AL592148 AL833718 BC015535 BC043142 BC067805
GenPept AAH15535 AAH43142 AAH67805 BAB14281 BAF82554 CAH56257 CAH73929 CAH73930 CAI40463 CAI40464

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca