InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DISP1

Summary

InnateDB Protein

IDBP-106839.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DISP1

Protein Name

dispatched homolog 1 (Drosophila)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000284476

InnateDB Gene

IDBG-106835 (DISP1)

Protein Structure

UniProt Annotation

Function

Functions in hedgehog (Hh) signaling. Regulates the release and extracellular accumulation of cholesterol-modified hedgehog proteins and is hence required for effective production of the Hh signal (By similarity). {ECO:0000250}.

Subcellular Localization

Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008158	hedgehog receptor activity
GO:0015197	peptide transporter activity

Biological Process

GO:0007224	smoothened signaling pathway
GO:0007225	patched ligand maturation
GO:0007368	determination of left/right symmetry
GO:0007389	pattern specification process
GO:0009880	embryonic pattern specification
GO:0009953	dorsal/ventral pattern formation
GO:0015833	peptide transport
GO:0060539	diaphragm development