Version 5.4
Homo sapiens Gene: DISP1
Summary
InnateDB Gene IDBG-106835.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DISP1
Gene Name dispatched homolog 1 (Drosophila)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000154309
Encoded Proteins
IDBP-106839
dispatched homolog 1 (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The pattern of cellular proliferation and differentiation that leads to normal development of embryonic structures often depends upon the localized production of secreted protein signals. Cells surrounding the source of a particular signal respond in a graded manner according to the effective concentration of the signal, and this response produces the pattern of cell types constituting the mature structure. A novel segment-polarity gene known as dispatched has been identified in Drosophila and its protein product is required for normal Hedgehog (Hh) signaling. This gene is one of two human homologs of Drosophila dispatched and, based on sequence identity to its mouse counterpart, the encoded protein may play an essential role in Hh patterning activities in the early embryo. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:222872271-223005995
Strand Forward strand
Band q41
Transcripts
ENST00000360254
ENST00000284476 ENSP00000284476
ENST00000495684
ENST00000482856
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008158 hedgehog receptor activity
GO:0015197 peptide transporter activity
Biological Process
GO:0007224 smoothened signaling pathway
GO:0007225 patched ligand maturation
GO:0007368 determination of left/right symmetry
GO:0007389 pattern specification process
GO:0009880 embryonic pattern specification
GO:0009953 dorsal/ventral pattern formation
GO:0015833 peptide transport
GO:0060539 diaphragm development
Cellular Component
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000030768
View Gene Order
Cross-References
SwissProt Q96F81
TrEMBL
UniProt Splice Variant
Entrez Gene 84976
UniGene Hs.528817 Hs.692324
RefSeq NM_032890 XM_005273335 XM_005273336 XM_006711592 XM_006711593 XM_006711594 XM_006711595
HUGO HGNC:19711
OMIM 607502
CCDS CCDS1536
HPRD
IMGT
EMBL AK023679 AK026114 AK098669 AL133092 BC007734 BC011542
GenPept AAH07734 AAH11542 BAB14637 BAB15365 BAC05373 CAB61406
RNA Seq Atlas 84976

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca