InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NVL

Summary

InnateDB Protein

IDBP-106896.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NVL

Protein Name

nuclear VCP-like

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000281701

InnateDB Gene

IDBG-106894 (NVL)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Nucleus, nucleolus {ECO:0000269PubMed:12429849, ECO:0000269PubMed:9286697}.

Disease Associations

Tissue Specificity

Widely expressed. Highest level of expression in heart, placenta, skeletal muscle, pancreas and retina. {ECO:0000269PubMed:9286697}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	10 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005524	ATP binding
GO:0009378	four-way junction helicase activity
GO:0016301	kinase activity
GO:0016887	ATPase activity
GO:0017111	nucleoside-triphosphatase activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006281	DNA repair
GO:0006310	DNA recombination
GO:0008152	metabolic process

Cellular Component

GO:0005634	nucleus
GO:0005730	nucleolus
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR003593 AAA+ ATPase domain
IPR003959 ATPase, AAA-type, core
IPR008824 DNA helicase, Holliday junction RuvB type, N-terminal
IPR010488 Zeta toxin domain
IPR011704 ATPase, dynein-related, AAA domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00004
PF07724
PF13304
PF05496
PF06414
PF07728

PRINTS

PIRSF

SMART

SM00382

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O15381