InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MIXL1

Summary

InnateDB Protein

IDBP-107020.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MIXL1

Protein Name

Mix paired-like homeobox

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000355775

InnateDB Gene

IDBG-107018 (MIXL1)

Protein Structure

UniProt Annotation

Function

Transcription factor that play a central role in proper axial mesendoderm morphogenesis and endoderm formation. Required for efficient differentiation of cells from the primitive streak stage to blood, by acting early in the recruitment and/or expansion of mesodermal progenitors to the hemangioblastic and hematopoietic lineages. Also involved in the morphogenesis of the heart and the gut during embryogenesis. Acts as a negative regulator of brachyury expression (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00108, ECO:0000269PubMed:12070013, ECO:0000269PubMed:17303500}.

Disease Associations

Tissue Specificity

Restricted to progenitors and secondary lymph tissues. In normal hematopoiesis, it is restricted to immature B- and T-lymphoid cells. Present in differentiating embryonic stem cells (at protein level). {ECO:0000269PubMed:12070013, ECO:0000269PubMed:16433620, ECO:0000269PubMed:17303500}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0000987	core promoter proximal region sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001085	RNA polymerase II transcription factor binding
GO:0001103	RNA polymerase II repressing transcription factor binding
GO:0001190	RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription
GO:0001205	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0002244	hematopoietic progenitor cell differentiation
GO:0006351	transcription, DNA-templated
GO:0007369	gastrulation
GO:0007492	endoderm development
GO:0007507	heart development
GO:0035987	endodermal cell differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048565	digestive tract development
GO:1901533	negative regulation of hematopoietic progenitor cell differentiation
GO:2000382	positive regulation of mesoderm development