Version 5.4
Homo sapiens Gene: MIXL1
Summary
InnateDB Gene IDBG-107018.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MIXL1
Gene Name Mix paired-like homeobox
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000185155
Encoded Proteins
IDBP-107020
Mix paired-like homeobox
IDBP-601115
Mix paired-like homeobox
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Homeodomain proteins, such as MIXL1, are transcription factors that regulate cell fate during development (Hart et al., 2005 [PubMed 15982639]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:226223618-226227054
Strand Forward strand
Band q42.12
Transcripts
ENST00000366810 ENSP00000355775
ENST00000542034 ENSP00000442439
ENST00000557734
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0000987 core promoter proximal region sequence-specific DNA binding
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001085 RNA polymerase II transcription factor binding
GO:0001103 RNA polymerase II repressing transcription factor binding
GO:0001190 RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription
GO:0001205 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677 DNA binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0001706 endoderm formation
GO:0002244 hematopoietic progenitor cell differentiation
GO:0006351 transcription, DNA-templated
GO:0007369 gastrulation
GO:0007492 endoderm development
GO:0007507 heart development
GO:0030097 hemopoiesis
GO:0035987 endodermal cell differentiation
GO:0042074 cell migration involved in gastrulation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048565 digestive tract development
GO:1901533 negative regulation of hematopoietic progenitor cell differentiation
GO:2000382 positive regulation of mesoderm development
Cellular Component
GO:0000790 nuclear chromatin
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000026497
View Gene Order
ENSBTAG00000002139
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.282079 Hs.723641 Hs.734947
RefSeq NM_001282402 NM_031944
HUGO
OMIM
CCDS CCDS1552 CCDS60432
HPRD 10086
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca