InnateDB Protein
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IDBP-107029.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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LIN9
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Protein Name
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lin-9 homolog (C. elegans)
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000329102
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InnateDB Gene
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IDBG-107021 (LIN9)
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Protein Structure
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Function |
Acts as a tumor suppressor. Inhibits DNA synthesis. Its ability to inhibit oncogenic transformation is mediated through its association with RB1. Plays a role in the expression of genes required for the G1/S transition. {ECO:0000269PubMed:15538385, ECO:0000269PubMed:16730350}.
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Subcellular Localization |
Nucleus, nucleoplasm {ECO:0000269PubMed:15538385, ECO:0000269PubMed:16730350}. Note=Found in perinucleolar structures. Associated with chromatin.
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Disease Associations |
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Tissue Specificity |
Expressed in thymus and testis. {ECO:0000269PubMed:15538385}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
17
[view]
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Protein-Protein |
17
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR010561
Protein LIN-9/Protein ALWAYS EARLY
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PFAM |
PF06584
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q5TKA1
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PhosphoSite |
PhosphoSite-Q5TKA1
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TrEMBL |
B1B047
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UniProt Splice Variant |
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Entrez Gene |
286826
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UniGene |
Hs.602486
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RefSeq |
NP_775106
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HUGO |
HGNC:30830
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OMIM |
609375
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CCDS |
CCDS1553
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HPRD |
13990
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IMGT |
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EMBL |
AF190323
AF190324
AK126177
AL359742
AY786184
BC043444
BC045625
BX284931
BX537869
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GenPept |
AAH43444
AAH45625
AAQ13710
AAQ13711
AAV41873
BAC86475
CAD97871
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