Version 5.4
Homo sapiens Protein: WNT3A
Summary
InnateDB Protein IDBP-107122.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol WNT3A
Protein Name wingless-type MMTV integration site family, member 3A
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000284523
InnateDB Gene IDBG-107120 (WNT3A)
Protein Structure
UniProt Annotation
Function Ligand for members of the frizzled family of seven transmembrane receptors. Wnt-3 and Wnt-3a play distinct roles in cell-cell signaling during morphogenesis of the developing neural tube.
Subcellular Localization Secreted, extracellular space, extracellular matrix.
Disease Associations
Tissue Specificity Moderately expressed in placenta and at low levels in adult lung, spleen, and prostate.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 8 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003713 transcription coactivator activity
GO:0005102 receptor binding
GO:0005109 frizzled binding
GO:0005110 frizzled-2 binding
GO:0005515 protein binding
GO:0019904 protein domain specific binding
GO:0048018 receptor agonist activity
Biological Process
GO:0001649 osteoblast differentiation
GO:0001701 in utero embryonic development
GO:0001756 somitogenesis
GO:0001934 positive regulation of protein phosphorylation
GO:0001947 heart looping
GO:0002092 positive regulation of receptor internalization
GO:0003136 negative regulation of heart induction by canonical Wnt receptor signaling pathway
GO:0007275 multicellular organismal development
GO:0007368 determination of left/right symmetry
GO:0007409 axonogenesis
GO:0007411 axon guidance
GO:0007498 mesoderm development
GO:0008284 positive regulation of cell proliferation
GO:0009952 anterior/posterior pattern specification
GO:0010387 COP9 signalosome assembly
GO:0010977 negative regulation of neuron projection development
GO:0016055 Wnt signaling pathway
GO:0021527 spinal cord association neuron differentiation
GO:0021766 hippocampus development
GO:0021846 cell proliferation in forebrain
GO:0021874 Wnt receptor signaling pathway involved in forebrain neuroblast division
GO:0021904 dorsal/ventral neural tube patterning
GO:0030097 hemopoiesis
GO:0030168 platelet activation
GO:0030182 neuron differentiation
GO:0030198 extracellular matrix organization
GO:0030879 mammary gland development
GO:0030890 positive regulation of B cell proliferation
GO:0032092 positive regulation of protein binding
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0034613 cellular protein localization
GO:0035413 positive regulation of catenin import into nucleus
GO:0035914 skeletal muscle cell differentiation
GO:0036342 post-anal tail morphogenesis
GO:0042472 inner ear morphogenesis
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045087 innate immune response (InnateDB)
GO:0045595 regulation of cell differentiation
GO:0045599 negative regulation of fat cell differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048103 somatic stem cell division
GO:0048337 positive regulation of mesodermal cell fate specification
GO:0048343 paraxial mesodermal cell fate commitment
GO:0048697 positive regulation of collateral sprouting in absence of injury
GO:0048843 negative regulation of axon extension involved in axon guidance
GO:0050768 negative regulation of neurogenesis
GO:0050770 regulation of axonogenesis
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
GO:0060021 palate development
GO:0060070 canonical Wnt signaling pathway
GO:0060923 cardiac muscle cell fate commitment
GO:0061098 positive regulation of protein tyrosine kinase activity
GO:0061184 positive regulation of dermatome development
GO:0061317 canonical Wnt receptor signaling pathway involved in cardiac muscle cell fate commitment
GO:0070507 regulation of microtubule cytoskeleton organization
GO:0070527 platelet aggregation
GO:0071300 cellular response to retinoic acid
GO:0090245 axis elongation involved in somitogenesis
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:2000049 positive regulation of cell-cell adhesion mediated by cadherin
GO:2000081 positive regulation of canonical Wnt receptor signaling pathway involved in controlling type B pancreatic cell proliferation
GO:2000727 positive regulation of cardiac muscle cell differentiation
Cellular Component
GO:0005576 extracellular region
GO:0005578 proteinaceous extracellular matrix
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005788 endoplasmic reticulum lumen
GO:0005796 Golgi lumen
GO:0005886 plasma membrane
GO:0009986 cell surface
Protein Structure and Domains
PDB ID
InterPro IPR005817 Wnt
IPR009141 Wnt-3 protein
PFAM PF00110
PRINTS PR01349
PR01843
PIRSF
SMART SM00097
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P56704
PhosphoSite PhosphoSite-P56704
TrEMBL
UniProt Splice Variant
Entrez Gene 89780
UniGene Hs.336930
RefSeq NP_149122
HUGO HGNC:15983
OMIM 606359
CCDS CCDS1564
HPRD 05897
IMGT
EMBL AB060284 AK056278 AL136379 BC103921 BC103922 BC103923
GenPept AAI03922 AAI03923 AAI03924 BAB61052 BAB71136 CAI23122

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca