InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NKD2

Summary

InnateDB Protein

IDBP-10726.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NKD2

Protein Name

naked cuticle homolog 2 (Drosophila)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000296849

InnateDB Gene

IDBG-10720 (NKD2)

Protein Structure

UniProt Annotation

Function

Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity (By similarity). Required for processing of TGFA and for targeting of TGFA to the basolateral membrane of polarized epithelial cells. {ECO:0000250, ECO:0000269PubMed:15064403, ECO:0000269PubMed:17553928}.

Subcellular Localization

Cell membrane. Cytoplasm. Cytoplasmic vesicle.

Disease Associations

Tissue Specificity

Expressed in kidney, lung, pancreas and spleen. {ECO:0000269PubMed:11604995}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	16 [view]
Protein-Protein	16 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0019838	growth factor binding
GO:0031625	ubiquitin protein ligase binding

Biological Process

GO:0006887	exocytosis
GO:0010954	positive regulation of protein processing
GO:0016055	Wnt signaling pathway
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0048210	Golgi vesicle fusion to target membrane
GO:0072661	protein targeting to plasma membrane
GO:0090004	positive regulation of establishment of protein localization to plasma membrane
GO:0090090	negative regulation of canonical Wnt signaling pathway

Cellular Component

GO:0016023	cytoplasmic membrane-bounded vesicle
GO:0016323	basolateral plasma membrane
GO:0016328	lateral plasma membrane
GO:0031410	cytoplasmic vesicle
GO:0071944	cell periphery