InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GALNT2

Summary

InnateDB Protein

IDBP-107348.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GALNT2

Protein Name

UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2 (GalNAc-T2)

Synonyms

GalNAc-T2;

Species

Homo sapiens

Ensembl Protein

ENSP00000355632

InnateDB Gene

IDBG-107346 (GALNT2)

Protein Structure

UniProt Annotation

Function

Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D- galactosamine residue to a serine or threonine residue on the protein receptor. Has a broad spectrum of substrates for peptides such as EA2, Muc5AC, Muc1a, Muc1b. Probably involved in O-linked glycosylation of the immunoglobulin A1 (IgA1) hinge region. {ECO:0000269PubMed:12438318, ECO:0000269PubMed:16434399, ECO:0000269PubMed:7592619, ECO:0000269PubMed:9295285}.

Subcellular Localization

Golgi apparatus, Golgi stack membrane {ECO:0000269PubMed:9394011}; Single-pass type II membrane protein {ECO:0000269PubMed:9394011}. Secreted {ECO:0000269PubMed:9394011}. Note=Resides preferentially in the trans and medial parts of the Golgi stack. A secreted form also exists.

Disease Associations

Tissue Specificity

Widely expressed. {ECO:0000269PubMed:7592619}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004653	polypeptide N-acetylgalactosaminyltransferase activity
GO:0030145	manganese ion binding

Biological Process

GO:0002378	immunoglobulin biosynthetic process
GO:0006493	protein O-linked glycosylation
GO:0016266	O-glycan processing
GO:0018242	protein O-linked glycosylation via serine
GO:0018243	protein O-linked glycosylation via threonine
GO:0043687	post-translational protein modification
GO:0044267	cellular protein metabolic process

Cellular Component

GO:0000139	Golgi membrane
GO:0005794	Golgi apparatus
GO:0005795	Golgi stack
GO:0016020	membrane
GO:0030173	integral component of Golgi membrane
GO:0032580	Golgi cisterna membrane
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome