InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GNPAT

Summary

InnateDB Protein

IDBP-107414.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GNPAT

Protein Name

glyceronephosphate O-acyltransferase

Synonyms

DAP-AT; DAPAT; DHAPAT;

Species

Homo sapiens

Ensembl Protein

ENSP00000355607

InnateDB Gene

IDBG-107412 (GNPAT)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Peroxisome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Matrix side {ECO:0000250}. Note=Exclusively localized to the lumenal side of the peroxisomal membrane. {ECO:0000250}.

Disease Associations

Rhizomelic chondrodysplasia punctata 2 (RCDP2) [MIM:222765]: A disease characterized by rhizomelic shortening of femur and humerus, vertebral disorders, cataract, cutaneous lesions and severe mental retardation. {ECO:0000269PubMed:11152660, ECO:0000269PubMed:21990100, ECO:0000269PubMed:9536089}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	10 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0016287	glycerone-phosphate O-acyltransferase activity
GO:0016290	palmitoyl-CoA hydrolase activity
GO:0016746	transferase activity, transferring acyl groups

Biological Process

GO:0006644	phospholipid metabolic process
GO:0006654	phosphatidic acid biosynthetic process
GO:0007416	synapse assembly
GO:0007584	response to nutrient
GO:0008152	metabolic process
GO:0008611	ether lipid biosynthetic process
GO:0021587	cerebellum morphogenesis
GO:0030913	paranodal junction assembly
GO:0042493	response to drug
GO:0042552	myelination
GO:0042594	response to starvation
GO:0044255	cellular lipid metabolic process
GO:0044281	small molecule metabolic process
GO:0046474	glycerophospholipid biosynthetic process
GO:0061024	membrane organization
GO:0070542	response to fatty acid