InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: GNPAT

Summary

InnateDB Gene

IDBG-107412.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GNPAT

Gene Name

glyceronephosphate O-acyltransferase

Synonyms

DAP-AT; DAPAT; DHAPAT

Species

Homo sapiens

Ensembl Gene

ENSG00000116906

Encoded Proteins

IDBP-107414

glyceronephosphate O-acyltransferase

IDBP-390134

glyceronephosphate O-acyltransferase

IDBP-390135

glyceronephosphate O-acyltransferase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes an enzyme located in the peroxisomal membrane which is essential to the synthesis of ether phospholipids. Mutations in this gene are associated with rhizomelic chondrodysplasia punctata. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:231241207-231277973

Strand

Forward strand

Band

q42.2

Transcripts

ENST00000366647	ENSP00000355607
ENST00000436239	ENSP00000402811
ENST00000416000	ENSP00000411640
ENST00000492459
ENST00000469332

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	10 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0008374	O-acyltransferase activity
GO:0016287	glycerone-phosphate O-acyltransferase activity
GO:0016290	palmitoyl-CoA hydrolase activity
GO:0016746	transferase activity, transferring acyl groups

Biological Process

GO:0006644	phospholipid metabolic process
GO:0006654	phosphatidic acid biosynthetic process
GO:0007416	synapse assembly
GO:0007584	response to nutrient
GO:0008152	metabolic process
GO:0008611	ether lipid biosynthetic process
GO:0021587	cerebellum morphogenesis
GO:0030913	paranodal junction assembly
GO:0042493	response to drug
GO:0042552	myelination
GO:0042594	response to starvation
GO:0044255	cellular lipid metabolic process
GO:0044281	small molecule metabolic process
GO:0046474	glycerophospholipid biosynthetic process
GO:0061024	membrane organization
GO:0070542	response to fatty acid

Cellular Component

GO:0005739	mitochondrion
GO:0005777	peroxisome
GO:0005778	peroxisomal membrane
GO:0005782	peroxisomal matrix
GO:0016020	membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000031985

View Gene Order

ENSBTAG00000010773

Not yet available

Pathways

NETPATH

REACTOME

REACT_1407

Plasmalogen biosynthesis pathway

REACT_120906

Synthesis of PA pathway

REACT_22258

Metabolism of lipids and lipoproteins pathway

REACT_16957

Peroxisomal lipid metabolism pathway

REACT_121401

Glycerophospholipid biosynthesis pathway

REACT_120870

Phospholipid metabolism pathway

REACT_111217

Metabolism pathway

KEGG

hsa00564

Glycerophospholipid metabolism pathway

hsa04146

Peroxisome pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

Q5TBH8

UniProt Splice Variant

Entrez Gene

8443

UniGene

Hs.498028 Hs.607434

RefSeq

NM_014236 XM_005273313

HUGO

HGNC:4416

OMIM

602744

CCDS

CCDS1592

HPRD

04120

IMGT

EMBL

AL117352 AL137801

GenPept

RNA Seq Atlas

8443