Version 5.4
Homo sapiens Protein: ARID4B
Summary
InnateDB Protein IDBP-107536.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ARID4B
Protein Name AT rich interactive domain 4B (RBP1-like)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000264183
InnateDB Gene IDBG-107534 (ARID4B)
Protein Structure
UniProt Annotation
Function Acts as a transcriptional repressor. May function in the assembly and/or enzymatic activity of the Sin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes. {ECO:0000269PubMed:12724404}.
Subcellular Localization Nucleus {ECO:0000255PROSITE- ProRule:PRU00355}. Cytoplasm {ECO:0000269PubMed:11481388, ECO:0000269PubMed:15247124}. Note=Cytoplasmic in breast cancer cells.
Disease Associations
Tissue Specificity Highly expressed in the testis and in breast, lung, colon, pancreatic and ovarian cancers. Expressed at low levels in the thymus, prostate and ovary. {ECO:0000269PubMed:11481388, ECO:0000269PubMed:12724404, ECO:0000269PubMed:15247124}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 15 [view]
Protein-Protein 15 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0003677 DNA binding
GO:0005515 protein binding
Biological Process
GO:0006349 regulation of gene expression by genetic imprinting
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0008150 biological_process
GO:0034773 histone H4-K20 trimethylation
GO:0036124 histone H3-K9 trimethylation
Cellular Component
GO:0005575 cellular_component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR001606 ARID/BRIGHT DNA-binding domain
IPR002999 Tudor domain
IPR012603 RBB1NT
IPR016197 Chromo domain-like
IPR025995 RNA binding activity-knot of a chromodomain
PFAM PF01388
PF00567
PF08169
PF11717
PRINTS
PIRSF
SMART SM00501
SM00333
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q4LE39
PhosphoSite PhosphoSite-Q4LE39
TrEMBL X6RCR8
UniProt Splice Variant
Entrez Gene 51742
UniGene Hs.575782
RefSeq NP_057458
HUGO HGNC:15550
OMIM 609696
CCDS CCDS31061
HPRD 10661
IMGT
EMBL AB030181 AB210032 AF083249 AF208045 AF214114 AF227899 AK023144 AL133418 AL133594 AL391994 AL732292 AY220790 BC048959 BC062536 BC104632 BC130418 BX648820 CH471098
GenPept AAD41239 AAF23433 AAF28341 AAF36964 AAH48959 AAH62536 AAI04633 AAI30419 AAO63590 BAA89794 BAB14428 BAE06114 CAB63731 CAI13747 CAI13749 CAI13751 CAI22961 CAI22962 CAI46047 EAW70008 EAW70011 EAW70012 EAW70013

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca