InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ARID4B

Summary

InnateDB Gene

IDBG-107534.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ARID4B

Gene Name

AT rich interactive domain 4B (RBP1-like)

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000054267

Encoded Proteins

IDBP-107536

AT rich interactive domain 4B (RBP1-like)

IDBP-107538

AT rich interactive domain 4B (RBP1-like)

IDBP-107540

AT rich interactive domain 4B (RBP1-like)

IDBP-390154

AT rich interactive domain 4B (RBP1-like)

IDBP-390155

AT rich interactive domain 4B (RBP1-like)

IDBP-390156

AT rich interactive domain 4B (RBP1-like)

IDBP-479429

AT rich interactive domain 4B (RBP1-like)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a protein with sequence similarity to retinoblastoma-binding protein-1. The encoded protein is a subunit of the histone deacetylase-dependant SIN3A transcriptional corepressor complex, which functions in diverse cellular processes including proliferation, differentiation, apoptosis, oncogenesis, and cell fate determination. The gene product is recognized by IgG antibody isolated from a breast cancer patient and appears to be a molecular marker associated with a broad range of human malignancies. Alternate transcriptional splice variants encoding different isoforms have been characterized. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:235131634-235328219

Strand

Reverse strand

Band

q42.3

Transcripts

ENST00000264183	ENSP00000264183
ENST00000349213	ENSP00000264184
ENST00000366603	ENSP00000355562
ENST00000421364	ENSP00000394663
ENST00000444620	ENSP00000416063
ENST00000418304	ENSP00000391497
ENST00000474953	ENSP00000420620
ENST00000474401
ENST00000491632
ENST00000494543
ENST00000471257
ENST00000466653
ENST00000462969

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	15 [view]
Protein-Protein	15 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0003677	DNA binding
GO:0005515	protein binding

Biological Process

GO:0006349	regulation of gene expression by genetic imprinting
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0008150	biological_process
GO:0034773	histone H4-K20 trimethylation
GO:0036124	histone H3-K9 trimethylation

Cellular Component

GO:0005575	cellular_component
GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000039219

View Gene Order

ENSBTAG00000000222

Not yet available

Pathways

NETPATH

REACTOME

REACT_200857

Epigenetic regulation of gene expression pathway

REACT_200856

NoRC negatively regulates rRNA expression pathway

REACT_228222

HDACs deacetylate histones pathway

REACT_172623

Chromatin organization pathway

REACT_172633

Chromatin modifying enzymes pathway

REACT_71

Gene Expression pathway

REACT_200834

Negative epigenetic regulation of rRNA expression pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.575782

RefSeq

NM_001206794 NM_016374 NM_031371 XM_005273160

HUGO

OMIM

CCDS

CCDS31060 CCDS31061

HPRD

10661

IMGT

EMBL

GenPept

RNA Seq Atlas