InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: LGALS8

Summary

InnateDB Protein

IDBP-107607.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LGALS8

Protein Name

lectin, galactoside-binding, soluble, 8

Synonyms

Gal-8; PCTA-1; PCTA1; Po66-CBP;

Species

Homo sapiens

Ensembl Protein

ENSP00000309576

InnateDB Gene

IDBG-107605 (LGALS8)

Protein Structure

UniProt Annotation

Function

Lectin with a marked preference for 3'-O-sialylated and 3'-O-sulfated glycans. {ECO:0000269PubMed:21288902}.

Subcellular Localization

Cytoplasm {ECO:0000305}.

Disease Associations

Tissue Specificity

Ubiquitous. Selective expression by prostate carcinomas versus normal prostate and benign prostatic hypertrophy.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 36 experimentally validated interaction(s) in this database.

Experimentally validated
Total	36 [view]
Protein-Protein	34 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0030246	carbohydrate binding

Biological Process

GO:0045087

innate immune response (InnateDB)

Cellular Component

GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0016020	membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR001079 Galectin, carbohydrate recognition domain
IPR008985 Concanavalin A-like lectin/glucanases superfamily

PFAM

PF00337

PRINTS

PIRSF

SMART

SM00276
SM00908

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O00214

PhosphoSite

PhosphoSite-O00214

TrEMBL

Q5T3P9

UniProt Splice Variant

Entrez Gene

3964

UniGene

Hs.735982

RefSeq

NP_963839

HUGO

HGNC:6569

OMIM

606099

CCDS

CCDS1611

HPRD

09356

IMGT

EMBL

AF074000 AF074001 AF074002 AF193805 AF193806 AF342815 AF342816 AF468213 AL136105 AL359921 BC015818 BC016486 L78132 X91790

GenPept

AAB51605 AAD45402 AAD45403 AAD45404 AAF19370 AAH15818 AAH16486 AAK16735 AAK16736 AAL77076 CAA62904 CAI13773 CAI13774