Version 5.4
Homo sapiens Gene: LGALS8
Summary
InnateDB Gene IDBG-107605.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LGALS8
Gene Name lectin, galactoside-binding, soluble, 8
Synonyms Gal-8; PCTA-1; PCTA1; Po66-CBP
Species Homo sapiens
Ensembl Gene ENSG00000116977
Encoded Proteins
IDBP-107607
lectin, galactoside-binding, soluble, 8
IDBP-107609
lectin, galactoside-binding, soluble, 8
IDBP-107611
lectin, galactoside-binding, soluble, 8
IDBP-583506
lectin, galactoside-binding, soluble, 8
IDBP-107621
lectin, galactoside-binding, soluble, 8
IDBP-295747
lectin, galactoside-binding, soluble, 8
IDBP-390163
lectin, galactoside-binding, soluble, 8
IDBP-390164
lectin, galactoside-binding, soluble, 8
IDBP-390165
lectin, galactoside-binding, soluble, 8
IDBP-390166
lectin, galactoside-binding, soluble, 8
IDBP-390167
lectin, galactoside-binding, soluble, 8
IDBP-390168
lectin, galactoside-binding, soluble, 8
IDBP-584788
lectin, galactoside-binding, soluble, 8
IDBP-587137
lectin, galactoside-binding, soluble, 8
IDBP-584589
lectin, galactoside-binding, soluble, 8
IDBP-598493
lectin, galactoside-binding, soluble, 8
IDBP-586090
lectin, galactoside-binding, soluble, 8
IDBP-592315
lectin, galactoside-binding, soluble, 8
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 20154696
LGALS8 (Gal-8), expressed in the intestinal tract, recognizes and kills human blood group antigen-expressing Escherichia coli while failing to alter the viability of other E. coli strains or other Gram-negative or Gram-positive organisms.
PMID 20208507
LGALS8 is part of the galectin family of proteins that have emerged as autonomous bacteria-killing agents, pointing to a principal role of these proteins in innate immunity.
Entrez Gene
Summary This gene encodes a member of the galectin family. Galectins are beta-galactoside-binding animal lectins with conserved carbohydrate recognition domains. The galectins have been implicated in many essential functions including development, differentiation, cell-cell adhesion, cell-matrix interaction, growth regulation, apoptosis, and RNA splicing. This gene is widely expressed in tumoral tissues and seems to be involved in integrin-like cell interactions. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:236518000-236552981
Strand Forward strand
Band q43
Transcripts
ENST00000352231 ENSP00000309576
ENST00000341872 ENSP00000342139
ENST00000238181 ENSP00000238181
ENST00000323938 ENSP00000434860
ENST00000366584 ENSP00000355543
ENST00000366583
ENST00000406509 ENSP00000385999
ENST00000430527 ENSP00000398630
ENST00000454943 ENSP00000405504
ENST00000450372 ENSP00000408657
ENST00000416919 ENSP00000410843
ENST00000434231 ENSP00000407428
ENST00000442397 ENSP00000413278
ENST00000481485 ENSP00000435632
ENST00000475670
ENST00000489586
ENST00000527974 ENSP00000431398
ENST00000526589 ENSP00000435460
ENST00000529489 ENSP00000437007
ENST00000532826
ENST00000528782
ENST00000526634 ENSP00000437040
ENST00000525042 ENSP00000431884
ENST00000528259
ENST00000526652
ENST00000529796
ENST00000532640
ENST00000525789
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 36 experimentally validated interaction(s) in this database.
Experimentally validated
Total 36 [view]
Protein-Protein 34 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0030246 carbohydrate binding
Biological Process
GO:0002317 plasma cell differentiation
GO:0031295 T cell costimulation
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000057554
View Gene Order
ENSBTAG00000013544
Not yet available
Cross-References
SwissProt O00214
TrEMBL B1ANM0 E9PJ77 E9PPL1 Q5T3P9
UniProt Splice Variant
Entrez Gene 3964
UniGene Hs.4082 Hs.656607 Hs.702392 Hs.735982
RefSeq NM_006499 NM_201543 NM_201544 NM_201545
HUGO HGNC:6569
OMIM 606099
CCDS CCDS1611 CCDS1612
HPRD 09356
IMGT
EMBL AF074000 AF074001 AF074002 AF193805 AF193806 AF342815 AF342816 AF468213 AL136105 AL359921 BC015818 BC016486 L78132 X91790
GenPept AAB51605 AAD45402 AAD45403 AAD45404 AAF19370 AAH15818 AAH16486 AAK16735 AAK16736 AAL77076 CAA62904 CAI13773 CAI13774
RNA Seq Atlas 3964

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca