InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ZP4

Summary

InnateDB Protein

IDBP-107658.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ZP4

Protein Name

zona pellucida glycoprotein 4

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000355529

InnateDB Gene

IDBG-107656 (ZP4)

Protein Structure

UniProt Annotation

Function

The mammalian zona pellucida, which mediates species- specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP4 may act as a sperm receptor.

Subcellular Localization

Processed zona pellucida sperm-binding protein 4: Secreted, extracellular space, extracellular matrix. Note=The glycoproteinaceous translucent extracellular matrix that surrounds the mammalian oocyte is called zona pellucida.Cell membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Oocytes.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0032190	acrosin binding

Biological Process

GO:0002922	positive regulation of humoral immune response
GO:0007338	single fertilization
GO:0007339	binding of sperm to zona pellucida
GO:0010737	protein kinase A signaling
GO:0032504	multicellular organism reproduction
GO:0035556	intracellular signal transduction
GO:0042102	positive regulation of T cell proliferation
GO:0045860	positive regulation of protein kinase activity
GO:0060478	acrosomal vesicle exocytosis
GO:0070528	protein kinase C signaling
GO:2000344	positive regulation of acrosome reaction
GO:2000360	negative regulation of binding of sperm to zona pellucida