Version 5.4
Homo sapiens Gene: ZP4
Summary
InnateDB Gene IDBG-107656.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ZP4
Gene Name zona pellucida glycoprotein 4
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000116996
Encoded Proteins
IDBP-107658
zona pellucida glycoprotein 4
IDBP-807620
zona pellucida glycoprotein 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed primarily of three or four glycoproteins with various functions during fertilization and preimplantation development. The nascent protein contains a N-terminal signal peptide sequence, a conserved ZP domain, a consensus furin cleavage site, and a C-terminal transmembrane domain. It is hypothesized that furin cleavage results in release of the mature protein from the plasma membrane for subsequent incorporation into the zona pellucida matrix. However, the requirement for furin cleavage in this process remains controversial based on mouse studies. Previously, this gene has been referred to as ZP1 or ZPB and thought to have similar functions as mouse Zp1. However, a human gene with higher similarity and chromosomal synteny to mouse Zp1 has been assigned the symbol ZP1 and this gene has been assigned the symbol ZP4. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:237877864-237890922
Strand Reverse strand
Band q43
Transcripts
ENST00000366570 ENSP00000355529
ENST00000611898 ENSP00000482304
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004871 signal transducer activity
GO:0032190 acrosin binding
Biological Process
GO:0002922 positive regulation of humoral immune response
GO:0007338 single fertilization
GO:0007339 binding of sperm to zona pellucida
GO:0010737 protein kinase A signaling
GO:0032504 multicellular organism reproduction
GO:0035556 intracellular signal transduction
GO:0042102 positive regulation of T cell proliferation
GO:0045860 positive regulation of protein kinase activity
GO:0060478 acrosomal vesicle exocytosis
GO:0070528 protein kinase C signaling
GO:2000344 positive regulation of acrosome reaction
GO:2000360 negative regulation of binding of sperm to zona pellucida
Cellular Component
GO:0005576 extracellular region
GO:0005578 proteinaceous extracellular matrix
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_163933
Interaction With The Zona Pellucida pathway
REACT_163914
Fertilization pathway
REACT_163848
Reproduction pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_021186
HUGO
OMIM
CCDS CCDS1615
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca