InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RGS7

Summary

InnateDB Protein

IDBP-107686.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RGS7

Protein Name

regulator of G-protein signaling 7

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000355520

InnateDB Gene

IDBG-107674 (RGS7)

Protein Structure

UniProt Annotation

Function

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(o)-alpha is specifically enhanced by the RGS6/GNG5 dimer. May play a role in synaptic vesicle exocytosis. May play important role in the rapid regulation of neuronal excitability and the cellular responses to short-lived stimulations (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0005096	GTPase activator activity
GO:0031681	G-protein beta-subunit binding

Biological Process

GO:0007186	G-protein coupled receptor signaling pathway
GO:0008277	regulation of G-protein coupled receptor protein signaling pathway
GO:0035556	intracellular signal transduction
GO:0038032	termination of G-protein coupled receptor signaling pathway
GO:0043547	positive regulation of GTPase activity