InnateDB Protein
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IDBP-107694.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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KMO
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Protein Name
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kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
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Synonyms
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dJ317G22.1;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000355517
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InnateDB Gene
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IDBG-107692 (KMO)
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Protein Structure
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Function |
Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract.
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Subcellular Localization |
Mitochondrion outer membrane {ECO:0000255HAMAP-Rule:MF_03018, ECO:0000269PubMed:9237672}; Multi-pass membrane protein {ECO:0000255HAMAP-Rule:MF_03018, ECO:0000269PubMed:9237672}.
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Disease Associations |
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Tissue Specificity |
Highest levels in placenta and liver. Detectable in kidney. {ECO:0000269PubMed:9237672}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR002938
Monooxygenase, FAD-binding
IPR003042
Aromatic-ring hydroxylase-like
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PFAM |
PF01494
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PRINTS |
PR00420
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
O15229
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PhosphoSite |
PhosphoSite-O15229
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TrEMBL |
A0A024R3S9
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UniProt Splice Variant |
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Entrez Gene |
8564
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UniGene |
Hs.731056
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RefSeq |
NP_003670
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HUGO |
HGNC:6381
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OMIM |
603538
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CCDS |
CCDS1618
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HPRD |
04642
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IMGT |
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EMBL |
AF056032
AL133390
CH471098
FO393423
Y13153
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GenPept |
AAC62615
CAA73613
EAW70094
EAW70096
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