Version 5.4
Homo sapiens Gene: KMO
Summary
InnateDB Gene IDBG-107692.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KMO
Gene Name kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
Synonyms dJ317G22.1
Species Homo sapiens
Ensembl Gene ENSG00000117009
Encoded Proteins
IDBP-107694
kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
IDBP-107696
kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
IDBP-107698
kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
IDBP-107700
kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a mitochondrion outer membrane protein that catalyzes the hydroxylation of L-tryptophan metabolite, L-kynurenine, to form L-3-hydroxykynurenine. Studies in yeast identified this gene as a therapeutic target for Huntington disease. [provided by RefSeq, Oct 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:241532134-241595642
Strand Forward strand
Band q43
Transcripts
ENST00000366559 ENSP00000355517
ENST00000366558 ENSP00000355516
ENST00000366557 ENSP00000355515
ENST00000366555 ENSP00000355513
ENST00000431245
ENST00000484628
ENST00000480967
ENST00000484229
ENST00000477907
ENST00000481087
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004502 kynurenine 3-monooxygenase activity
GO:0016174 NAD(P)H oxidase activity
GO:0050660 flavin adenine dinucleotide binding
Biological Process
GO:0006569 tryptophan catabolic process
GO:0009651 response to salt stress
GO:0019441 tryptophan catabolic process to kynurenine
GO:0019674 NAD metabolic process
GO:0019805 quinolinate biosynthetic process
GO:0034354 'de novo' NAD biosynthetic process from tryptophan
GO:0034641 cellular nitrogen compound metabolic process
GO:0043420 anthranilate metabolic process
GO:0044281 small molecule metabolic process
GO:0055114 oxidation-reduction process
GO:0070189 kynurenine metabolic process
Cellular Component
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0005743 mitochondrial inner membrane
GO:0005829 cytosol
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000039783
View Gene Order
ENSBTAG00000014439
Not yet available
Pathways
NETPATH
REACTOME
REACT_916
Tryptophan catabolism pathway
REACT_13
Metabolism of amino acids and derivatives pathway
REACT_111217
Metabolism pathway
KEGG
hsa00380
Tryptophan metabolism pathway
INOH
INOH website
Tryptophan degradation pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.409081 Hs.731056
RefSeq NM_003679 XM_005273337
HUGO
OMIM
CCDS CCDS1618
HPRD 04642
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca