InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KMO

Summary

InnateDB Protein

IDBP-107698.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KMO

Protein Name

kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)

Synonyms

dJ317G22.1;

Species

Homo sapiens

Ensembl Protein

ENSP00000355515

InnateDB Gene

IDBG-107692 (KMO)

Protein Structure

UniProt Annotation

Function

Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract.

Subcellular Localization

Mitochondrion outer membrane {ECO:0000255HAMAP-Rule:MF_03018, ECO:0000269PubMed:9237672}; Multi-pass membrane protein {ECO:0000255HAMAP-Rule:MF_03018, ECO:0000269PubMed:9237672}.

Disease Associations

Tissue Specificity

Highest levels in placenta and liver. Detectable in kidney. {ECO:0000269PubMed:9237672}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004502	kynurenine 3-monooxygenase activity
GO:0016174	NAD(P)H oxidase activity
GO:0050660	flavin adenine dinucleotide binding

Biological Process

GO:0006569	tryptophan catabolic process
GO:0009651	response to salt stress
GO:0019805	quinolinate biosynthetic process
GO:0034354	'de novo' NAD biosynthetic process from tryptophan
GO:0034641	cellular nitrogen compound metabolic process
GO:0043420	anthranilate metabolic process
GO:0044281	small molecule metabolic process
GO:0055114	oxidation-reduction process
GO:0070189	kynurenine metabolic process