Version 5.4
Homo sapiens Protein: SDCCAG8
Summary
InnateDB Protein IDBP-107746.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SDCCAG8
Protein Name serologically defined colon cancer antigen 8
Synonyms BBS16; CCCAP; CCCAP SLSN7; hCCCAP; NPHP10; NY-CO-8; SLSN7;
Species Homo sapiens
Ensembl Protein ENSP00000355499
InnateDB Gene IDBG-107744 (SDCCAG8)
Protein Structure
UniProt Annotation
Function Plays a role in the establishment of cell polarity and epithelial lumen formation (By similarity). May play a role in ciliogenesis. {ECO:0000250}.
Subcellular Localization Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cell junction. Note=Located at the distal ends of both centrioles and colocalizes to centrosomes throughout the cell cycle.Isoform 2: Cytoplasm.
Disease Associations Senior-Loken syndrome 7 (SLSN7) [MIM:613615]: A renal- retinal disorder characterized by progressive wasting of the filtering unit of the kidney (nephronophthisis), with or without medullary cystic renal disease, and progressive eye disease. Typically this disorder becomes apparent during the first year of life. {ECO:0000269PubMed:20835237}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Tissue Specificity Expressed in thymus, prostate, testis, ovary, small intestine, colon, mucosa, colon and renal cancer tumors. {ECO:0000269PubMed:9610721}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000278 mitotic cell cycle
GO:0030010 establishment of cell polarity
GO:0035148 tube formation
Cellular Component
GO:0005813 centrosome
GO:0005814 centriole
GO:0005829 cytosol
GO:0005911 cell-cell junction
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q86SQ7
PhosphoSite PhosphoSite-Q86SQ7
TrEMBL A6NCS9
UniProt Splice Variant
Entrez Gene 10806
UniGene
RefSeq NP_006633
HUGO HGNC:10671
OMIM 613524
CCDS CCDS31075
HPRD 10215
IMGT
EMBL AC092782 AC092806 AC096539 AF039690 AF161348 AF250731 BC032454 BC045832
GenPept AAC18039 AAF28908 AAH32454 AAH45832 AAO27830

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca