InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TFB2M

Summary

InnateDB Protein

IDBP-107843.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TFB2M

Protein Name

transcription factor B2, mitochondrial

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000355471

InnateDB Gene

IDBG-107841 (TFB2M)

Protein Structure

UniProt Annotation

Function

S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity. Compared to TFB1M, it activates transcription of mitochondrial DNA more efficiently, while it has less methyltransferase activity. {ECO:0000269PubMed:12068295, ECO:0000269PubMed:12897151, ECO:0000269PubMed:15526033, ECO:0000269PubMed:20410300}.

Subcellular Localization

Mitochondrion.

Disease Associations

Tissue Specificity

Ubiquitously expressed. {ECO:0000269PubMed:12068295}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.

Experimentally validated
Total	9 [view]
Protein-Protein	7 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000179	rRNA (adenine-N6,N6-)-dimethyltransferase activity
GO:0003712	transcription cofactor activity
GO:0008649	rRNA methyltransferase activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000154	rRNA modification
GO:0006355	regulation of transcription, DNA-templated
GO:0006390	transcription from mitochondrial promoter
GO:0006391	transcription initiation from mitochondrial promoter
GO:0010467	gene expression
GO:0031167	rRNA methylation
GO:0045893	positive regulation of transcription, DNA-templated

Cellular Component

GO:0005739	mitochondrion
GO:0005759	mitochondrial matrix
GO:0042645	mitochondrial nucleoid

Protein Structure and Domains

PDB ID

InterPro

IPR001737 Ribosomal RNA adenine methylase transferase
IPR016861 Mitochondrial dimethyladenosine transferase 2, mitochondrial precursor
IPR020598 Ribosomal RNA adenine methylase transferase, N-terminal
IPR029063 S-adenosyl-L-methionine-dependent methyltransferase-like

PFAM

PF00398

PRINTS

PIRSF

PIRSF027833

SMART

SM00650

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt