InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SLC12A7

Summary

InnateDB Protein

IDBP-10793.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC12A7

Protein Name

solute carrier family 12 (potassium/chloride transporters), member 7

Synonyms

KCC4;

Species

Homo sapiens

Ensembl Protein

ENSP00000264930

InnateDB Gene

IDBG-10791 (SLC12A7)

Protein Structure

UniProt Annotation

Function

Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May mediate K(+) uptake into Deiters' cells in the cochlea and contribute to K(+) recycling in the inner ear. Important for the survival of cochlear outer and inner hair cells and the maintenance of the organ of Corti. May be required for basolateral Cl(-) extrusion in the kidney and contribute to renal acidification (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Detected in muscle, brain, lung, heart and kidney.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0015377	cation:chloride symporter activity
GO:0015379	potassium:chloride symporter activity
GO:0019901	protein kinase binding

Biological Process

GO:0006810	transport
GO:0006811	ion transport
GO:0006813	potassium ion transport
GO:0006821	chloride transport
GO:0006884	cell volume homeostasis
GO:0055085	transmembrane transport
GO:1902476	chloride transmembrane transport