InnateDB Protein
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IDBP-10827.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SLC39A14
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Protein Name
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solute carrier family 39 (zinc transporter), member 14
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Synonyms
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cig19; LZT-Hs4; NET34; ZIP14;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000352779
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InnateDB Gene
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IDBG-10825 (SLC39A14)
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Protein Structure
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Function |
May mediate cellular uptake of nontransferrin-bound iron (By similarity). Broad-scope metal ion transporter with a preference for zinc uptake. {ECO:0000250, ECO:0000269PubMed:15642354}.
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Subcellular Localization |
Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cell projection, lamellipodium {ECO:0000269PubMed:12659941, ECO:0000269PubMed:15642354}. Note=Localized to the plasma membrane and also found colocalized with F-actin concentrated on lamellipodiae.
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Disease Associations |
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Tissue Specificity |
Ubiquitously expressed, with increased expression in liver, pancreas, fetal liver, thyroid gland, left and right ventricle, right atrium and fetal heart. Weakly expressed in spleen, thymus, and peripheral blood leukocytes. {ECO:0000269PubMed:15642354, ECO:0000269PubMed:7584044}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
5
[view]
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Protein-Protein |
5
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0005385
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zinc ion transmembrane transporter activity
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GO:0015093
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ferrous iron transmembrane transporter activity
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GO:0046873
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metal ion transmembrane transporter activity
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR003689
Zinc/iron permease
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PFAM |
PF02535
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q15043
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PhosphoSite |
PhosphoSite-Q15043
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TrEMBL |
E5RJG5
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UniProt Splice Variant |
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Entrez Gene |
23516
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UniGene |
Hs.611826
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RefSeq |
NP_056174
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HUGO |
HGNC:20858
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OMIM |
608736
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CCDS |
CCDS6030
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HPRD |
12288
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IMGT |
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EMBL |
AC087854
AC105910
AK172810
AK295807
BC015770
CH471080
D31887
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GenPept |
AAH15770
BAA06685
BAD18780
BAG58625
EAW63681
EAW63682
EAW63683
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