Version 5.4
Homo sapiens Gene: SLC39A14
Summary
InnateDB Gene IDBG-10825.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC39A14
Gene Name solute carrier family 39 (zinc transporter), member 14
Synonyms cig19; LZT-Hs4; NET34; ZIP14
Species Homo sapiens
Ensembl Gene ENSG00000104635
Encoded Proteins
IDBP-10827
solute carrier family 39 (zinc transporter), member 14
IDBP-10831
solute carrier family 39 (zinc transporter), member 14
IDBP-10833
solute carrier family 39 (zinc transporter), member 14
IDBP-10835
solute carrier family 39 (zinc transporter), member 14
IDBP-483120
solute carrier family 39 (zinc transporter), member 14
IDBP-480254
solute carrier family 39 (zinc transporter), member 14
IDBP-478000
solute carrier family 39 (zinc transporter), member 14
IDBP-477361
solute carrier family 39 (zinc transporter), member 14
IDBP-481575
solute carrier family 39 (zinc transporter), member 14
IDBP-483883
solute carrier family 39 (zinc transporter), member 14
IDBP-483034
solute carrier family 39 (zinc transporter), member 14
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Zinc is an essential cofactor for hundreds of enzymes. It is involved in protein, nucleic acid, carbohydrate, and lipid metabolism, as well as in the control of gene transcription, growth, development, and differentiation. SLC39A14 belongs to a subfamily of proteins that show structural characteristics of zinc transporters (Taylor and Nicholson, 2003 [PubMed 12659941]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:22367249-22434129
Strand Forward strand
Band p21.3
Transcripts
ENST00000359741 ENSP00000352779
ENST00000240095 ENSP00000240095
ENST00000381237 ENSP00000370635
ENST00000289952 ENSP00000289952
ENST00000520644 ENSP00000428789
ENST00000524285 ENSP00000430315
ENST00000520832 ENSP00000428905
ENST00000519960 ENSP00000430629
ENST00000522881 ENSP00000429328
ENST00000517552 ENSP00000430564
ENST00000517370 ENSP00000427981
ENST00000518348
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005385 zinc ion transmembrane transporter activity
GO:0015093 ferrous iron transmembrane transporter activity
GO:0046873 metal ion transmembrane transporter activity
Biological Process
GO:0006826 iron ion transport
GO:0006829 zinc ion transport
GO:0006882 cellular zinc ion homeostasis
GO:0015684 ferrous iron transport
GO:0030001 metal ion transport
GO:0055085 transmembrane transport
GO:0071577 zinc ion transmembrane transport
GO:0071578 zinc ion transmembrane import
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030027 lamellipodium
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000022094
View Gene Order
ENSBTAG00000019225
Not yet available
Pathways
NETPATH
REACTOME
REACT_20603
Zinc influx into cells by the SLC39 gene family pathway
REACT_20547
Metal ion SLC transporters pathway
REACT_19305
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_20530
Zinc transporters pathway
REACT_19118
SLC-mediated transmembrane transport pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL E5RFF5 E5RFZ8 E5RGA7 E5RIP4 E5RJ40 E5RJG5
UniProt Splice Variant
Entrez Gene 23516
UniGene Hs.491232 Hs.594244 Hs.611826
RefSeq NM_001128431 NM_001135153 NM_001135154 NM_015359 XM_005273463 XM_005273464 XM_005273465 XM_005273466 XM_006716323 XM_006716324
HUGO HGNC:20858
OMIM 608736
CCDS CCDS47822 CCDS47823 CCDS6030
HPRD 12288
IMGT
EMBL AC087854 AC105910
GenPept
RNA Seq Atlas 23516

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca