Version 5.4
Homo sapiens Protein: SLC39A14
Summary
InnateDB Protein IDBP-10835.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC39A14
Protein Name solute carrier family 39 (zinc transporter), member 14
Synonyms cig19; LZT-Hs4; NET34; ZIP14;
Species Homo sapiens
Ensembl Protein ENSP00000289952
InnateDB Gene IDBG-10825 (SLC39A14)
Protein Structure
UniProt Annotation
Function May mediate cellular uptake of nontransferrin-bound iron (By similarity). Broad-scope metal ion transporter with a preference for zinc uptake. {ECO:0000250, ECO:0000269PubMed:15642354}.
Subcellular Localization Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cell projection, lamellipodium {ECO:0000269PubMed:12659941, ECO:0000269PubMed:15642354}. Note=Localized to the plasma membrane and also found colocalized with F-actin concentrated on lamellipodiae.
Disease Associations
Tissue Specificity Ubiquitously expressed, with increased expression in liver, pancreas, fetal liver, thyroid gland, left and right ventricle, right atrium and fetal heart. Weakly expressed in spleen, thymus, and peripheral blood leukocytes. {ECO:0000269PubMed:15642354, ECO:0000269PubMed:7584044}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005385 zinc ion transmembrane transporter activity
GO:0046873 metal ion transmembrane transporter activity
Biological Process
GO:0006882 cellular zinc ion homeostasis
GO:0030001 metal ion transport
GO:0055085 transmembrane transport
GO:0071577 zinc ion transmembrane transport
GO:0071578 zinc ion transmembrane import
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030027 lamellipodium
Protein Structure and Domains
PDB ID
InterPro IPR003689 Zinc/iron permease
PFAM PF02535
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q15043
PhosphoSite PhosphoSite-Q15043
TrEMBL E5RJG5
UniProt Splice Variant
Entrez Gene 23516
UniGene Hs.611826
RefSeq NP_001128625
HUGO HGNC:20858
OMIM 608736
CCDS CCDS47823
HPRD 12288
IMGT
EMBL AC087854 AC105910 AK172810 AK295807 BC015770 CH471080 D31887
GenPept AAH15770 BAA06685 BAD18780 BAG58625 EAW63681 EAW63682 EAW63683

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca