Version 5.4
Homo sapiens Protein: PARVB
Summary
InnateDB Protein IDBP-10892.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PARVB
Protein Name parvin, beta
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000342492
InnateDB Gene IDBG-10888 (PARVB)
Protein Structure
UniProt Annotation
Function Adapter protein that plays a role in integrin signaling via ILK and in activation of the GTPases CDC42 and RAC1 by guanine exchange factors, such as ARHGEF6. Is involved in the reorganization of the actin cytoskeleton and formation of lamellipodia. Plays a role in cell adhesion, cell spreading, establishment or maintenance of cell polarity, and cell migration. {ECO:0000269PubMed:11402068, ECO:0000269PubMed:15005707, ECO:0000269PubMed:15159419, ECO:0000269PubMed:15284246, ECO:0000269PubMed:18325335}.
Subcellular Localization Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cell projection, lamellipodium. Cytoplasm, myofibril, sarcomere. Cytoplasm, myofibril, sarcomere, Z line. Note=Constituent of focal adhesions. Detected at the tips of the leading edge of cells. Colocalizes with F-actin at the tips of lamellipodia.
Disease Associations
Tissue Specificity Expressed predominantly in heart and skeletal muscle. {ECO:0000269PubMed:11402068, ECO:0000269PubMed:11722847}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 15 [view]
Protein-Protein 14 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005515 protein binding
Biological Process
GO:0007155 cell adhesion
GO:0030031 cell projection assembly
GO:0030032 lamellipodium assembly
GO:0031532 actin cytoskeleton reorganization
GO:0034329 cell junction assembly
GO:0071963 establishment or maintenance of cell polarity regulating cell shape
Cellular Component
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0005925 focal adhesion
GO:0030018 Z disc
GO:0030027 lamellipodium
Protein Structure and Domains
PDB ID
InterPro IPR001715 Calponin homology domain
PFAM PF00307
PRINTS
PIRSF
SMART SM00033
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9HBI1
PhosphoSite PhosphoSite-Q9HBI1
TrEMBL
UniProt Splice Variant
Entrez Gene 29780
UniGene Hs.475074
RefSeq NP_037459
HUGO HGNC:14653
OMIM 608121
CCDS CCDS14056
HPRD 16284
IMGT
EMBL AB048276 AF151814 AF237769 AF303887 AK313957 AL031595 AL033543 AL035398 AL159142 BC039811 BC046103 BG743702 CH471138 Z82174 Z82178
GenPept AAD34051 AAG27171 AAH46103 AAL08219 BAB62077 BAG36673 CAB76900 CAI17969 CAI18767 CAI22312 CAQ06491 CAQ06493 CAQ08141 CAQ08144 CAQ08662 CAQ09485 EAW73328

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca