Version 5.4
Homo sapiens Gene: PARVB
Summary
InnateDB Gene IDBG-10888.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PARVB
Gene Name parvin, beta
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000188677
Encoded Proteins
IDBP-10892
parvin, beta
IDBP-295729
parvin, beta
IDBP-295717
parvin, beta
IDBP-379423
parvin, beta
IDBP-810110
parvin, beta
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the parvin family of actin-binding proteins, which play a role in cytoskeleton organization and cell adhesion. These proteins are associated with focal contacts and contain calponin homology domains that bind to actin filaments. This family member binds to alphaPIX and alpha-actinin, and it can inhibit the activity of integrin-linked kinase. This protein also functions in tumor suppression. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:43999211-44172949
Strand Forward strand
Band q13.31
Transcripts
ENST00000338758 ENSP00000342492
ENST00000406477 ENSP00000384515
ENST00000402876
ENST00000404989 ENSP00000384353
ENST00000444029 ENSP00000393758
ENST00000477795
ENST00000495824
ENST00000484345
ENST00000477438
ENST00000619710 ENSP00000482511
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 15 [view]
Protein-Protein 14 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005515 protein binding
Biological Process
GO:0007155 cell adhesion
GO:0030031 cell projection assembly
GO:0030032 lamellipodium assembly
GO:0031532 actin cytoskeleton reorganization
GO:0034329 cell junction assembly
GO:0071963 establishment or maintenance of cell polarity regulating cell shape
Cellular Component
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0005925 focal adhesion
GO:0030018 Z disc
GO:0030027 lamellipodium
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000022438
View Gene Order
ENSBTAG00000021978
Not yet available
Pathways
NETPATH
REACTOME
REACT_20580
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components pathway
REACT_20649
Cell-extracellular matrix interactions pathway
REACT_111155
Cell-Cell communication pathway
REACT_20676
Cell junction organization pathway
KEGG
hsa04510
Focal adhesion pathway
INOH
PID NCI
ilk_pathway
Integrin-linked kinase signaling
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.475074
RefSeq NM_001003828 NM_001243385 NM_001243386 NM_013327 XM_005261593 XM_005261594 XM_005261595 XM_005261596 XM_006724236
HUGO
OMIM
CCDS CCDS14056 CCDS46724 CCDS58808 CCDS74874
HPRD 16284
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca