InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SORBS3

Summary

InnateDB Protein

IDBP-10980.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SORBS3

Protein Name

sorbin and SH3 domain containing 3

Synonyms

SCAM-1; SCAM1; SH3D4;

Species

Homo sapiens

Ensembl Protein

ENSP00000240123

InnateDB Gene

IDBG-10978 (SORBS3)

Protein Structure

UniProt Annotation

Function

Vinexin alpha isoform promotes up-regulation of actin stress fiber formation. Vinexin beta isoform plays a role in cell spreading and enhances the activation of JNK/SAPK in response to EGF stimulation by using its third SH3 domain.

Subcellular Localization

Isoform Alpha: Cell junction {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Localized at cell- extracellular matrix junctions (By similarity). Both isoforms were localized at focal adhesion and cell-cell adhesion sites. {ECO:0000250}.Isoform Beta: Cell junction {ECO:0000250}. Nucleus. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Localized at cell-extracellular matrix junctions (By similarity). Both isoforms were localized at focal adhesion and cell-cell adhesion sites, vinexin beta was also found in the nucleus. {ECO:0000250}.

Disease Associations

Tissue Specificity

Both isoforms are expressed in different tissues like heart, placenta, brain, skeletal muscle and pancreas. Isoform beta is especially found in liver.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 47 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	47 [view]
Protein-Protein	47 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005200	structural constituent of cytoskeleton
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0017166	vinculin binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006936	muscle contraction
GO:0007015	actin filament organization
GO:0007155	cell adhesion
GO:0031589	cell-substrate adhesion
GO:0043410	positive regulation of MAPK cascade
GO:0051495	positive regulation of cytoskeleton organization
GO:0051496	positive regulation of stress fiber assembly