InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SHC4

Summary

InnateDB Protein

IDBP-11295.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SHC4

Protein Name

SHC (Src homology 2 domain containing) family, member 4

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000329668

InnateDB Gene

IDBG-11293 (SHC4)

Protein Structure

UniProt Annotation

Function

Activates both Ras-dependent and Ras-independent migratory pathways in melanomas. Contributes to the early phases of agrin-induced tyrosine phosphorylation of CHRNB1. {ECO:0000269PubMed:17409413}.

Subcellular Localization

Cell junction, synapse, postsynaptic cell membrane. Note=Colocalized with MUSK at the neuromuscular junction. {ECO:0000250}.

Disease Associations

Tissue Specificity

Only expressed in melanomas. Weakly expressed in normal melanocytes and benign nevi. Highly expressed at the transition from radial growth phase to vertical growth phase and metastatic melanomas, when tumor cells acquire migratory competence and invasive potential. {ECO:0000269PubMed:17409413}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019904	protein domain specific binding
GO:0030971	receptor tyrosine kinase binding

Biological Process

GO:0006915	apoptotic process
GO:0008284	positive regulation of cell proliferation
GO:0010468	regulation of gene expression
GO:0035556	intracellular signal transduction
GO:0048863	stem cell differentiation