InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GHRHR

Summary

InnateDB Protein

IDBP-11354.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GHRHR

Protein Name

growth hormone releasing hormone receptor

Synonyms

GHRFR; GRFR; IGHD1B;

Species

Homo sapiens

Ensembl Protein

ENSP00000320180

InnateDB Gene

IDBG-11350 (GHRHR)

Protein Structure

UniProt Annotation

Function

Receptor for GRF, coupled to G proteins which activate adenylyl cyclase. Stimulates somatotroph cell growth, growth hormone gene transcription and growth hormone secretion.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Growth hormone deficiency, isolated, 1B (IGHD1B) [MIM:612781]: An autosomal recessive deficiency of growth hormone leading to short stature. Patients have low but detectable levels of growth hormone, significantly retarded bone age, and a positive response and immunologic tolerance to growth hormone therapy. {ECO:0000269PubMed:10084571, ECO:0000269PubMed:11232012, ECO:0000269PubMed:12534354}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Pituitary gland.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0005515	protein binding
GO:0016520	growth hormone-releasing hormone receptor activity
GO:0017046	peptide hormone binding
GO:0019838	growth factor binding

Biological Process

GO:0007165	signal transduction
GO:0007166	cell surface receptor signaling pathway
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0007189	adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0007190	activation of adenylate cyclase activity
GO:0007595	lactation
GO:0008284	positive regulation of cell proliferation
GO:0008340	determination of adult lifespan
GO:0019933	cAMP-mediated signaling
GO:0021984	adenohypophysis development
GO:0030104	water homeostasis
GO:0030252	growth hormone secretion
GO:0030816	positive regulation of cAMP metabolic process
GO:0030819	positive regulation of cAMP biosynthetic process
GO:0030879	mammary gland development
GO:0032868	response to insulin
GO:0032869	cellular response to insulin stimulus
GO:0033143	regulation of intracellular steroid hormone receptor signaling pathway
GO:0040018	positive regulation of multicellular organism growth
GO:0042445	hormone metabolic process
GO:0043567	regulation of insulin-like growth factor receptor signaling pathway
GO:0043568	positive regulation of insulin-like growth factor receptor signaling pathway
GO:0043627	response to estrogen
GO:0046887	positive regulation of hormone secretion
GO:0048469	cell maturation
GO:0048609	multicellular organismal reproductive process
GO:0051246	regulation of protein metabolic process
GO:0051384	response to glucocorticoid
GO:0060124	positive regulation of growth hormone secretion
GO:0060133	somatotropin secreting cell development

Cellular Component

GO:0005637	nuclear inner membrane
GO:0005640	nuclear outer membrane
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016363	nuclear matrix
GO:0030141	secretory granule

Protein Structure and Domains

PDB ID

InterPro

IPR000832 GPCR, family 2, secretin-like
IPR001771 GPCR, family 2, vasoactive intestinal peptide receptor 1
IPR001879 GPCR, family 2, extracellular hormone receptor domain
IPR003288 GPCR, family 2, growth hormone-releasing hormone receptor
IPR017981 GPCR, family 2-like

PFAM

PF00002
PF02793

PRINTS

PR00249
PR01154
PR01352

PIRSF

SMART

SM00008

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt