InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: UPK3A

Summary

InnateDB Protein

IDBP-11395.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

UPK3A

Protein Name

uroplakin 3A

Synonyms

UP3A; UPIII; UPIIIA; UPK3;

Species

Homo sapiens

Ensembl Protein

ENSP00000216211

InnateDB Gene

IDBG-11393 (UPK3A)

Protein Structure

UniProt Annotation

Function

Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in AUM-cytoskeleton interaction in terminally differentiated urothelial cells. It also contributes to the formation of urothelial glycocalyx which may play an important role in preventing bacterial adherence (By similarity). {ECO:0000250}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Heterodimer formation with UPK1B is a prerequisite to exit out of the endoplasmic reticulum (ER). {ECO:0000250}.

Disease Associations

Note=Mutations in UPK3A have been detected in patients with renal adyplasia suggesting a possible involvement of this gene in kidney and urinary tract anomalies.

Tissue Specificity

Expressed in ureter. {ECO:0000269PubMed:9846985}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession

GO Term

Biological Process

GO:0000902	cell morphogenesis
GO:0001822	kidney development
GO:0006833	water transport
GO:0015840	urea transport
GO:0030855	epithelial cell differentiation
GO:0055075	potassium ion homeostasis
GO:0055078	sodium ion homeostasis
GO:0060157	urinary bladder development

Cellular Component

GO:0005789	endoplasmic reticulum membrane
GO:0016021	integral component of membrane
GO:0016324	apical plasma membrane
GO:0070062	extracellular vesicular exosome