Homo sapiens Protein: KCNIP4
Summary
InnateDB Protein IDBP-11483.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KCNIP4
Protein Name Kv channel interacting protein 4
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000371585
InnateDB Gene IDBG-11479 (KCNIP4)
Protein Structure
UniProt Annotation
Function Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Probably modulates channels density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates KCND2/Kv4.2 and KCND3/Kv4.3 currents (By similarity). {ECO:0000250}.
Subcellular Localization Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity Predominantly expressed in brain. {ECO:0000269PubMed:11847232}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005244 voltage-gated ion channel activity
GO:0005267 potassium channel activity
GO:0005509 calcium ion binding
Biological Process
GO:0007165 signal transduction
GO:0034765 regulation of ion transmembrane transport
GO:0071805 potassium ion transmembrane transport
Cellular Component
GO:0005578 proteinaceous extracellular matrix
GO:0005886 plasma membrane
Protein Structure and Domains
PDB ID
InterPro IPR002048 EF-hand domain
IPR019577 SPARC/Testican, calcium-binding domain
PFAM PF00036
PF13202
PF13405
PF10591
PRINTS
PIRSF
SMART SM00054
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6PIL6
PhosphoSite PhosphoSite-Q6PIL6
TrEMBL Q8TDF2
UniProt Splice Variant
Entrez Gene 80333
UniGene Hs.705981
RefSeq NP_671712
HUGO HGNC:30083
OMIM 608182
CCDS CCDS3428
HPRD 12184
IMGT
EMBL AC096576 AC097505 AC098597 AC104065 AC107462 AC108147 AC109360 AC109636 AC110296 AC110612 AC113606 AC116641 AF302044 AF305072 AF367023 AF367024 AF453244 AF453246 AK289922 AY029176 AY118170 BC032520 CH471069 DQ148487 DQ148488 DQ148489 DQ148490 DQ148491
GenPept AAG36974 AAG36977 AAH32520 AAK31594 AAK53712 AAK53713 AAL86767 AAL86769 AAM81578 AAY40911 AAZ77804 AAZ77805 AAZ77806 AAZ77807 AAZ77808 BAF82611 EAW92798