Homo sapiens Gene: KCNIP4
Summary
InnateDB Gene IDBG-11479.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KCNIP4
Gene Name Kv channel interacting protein 4
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000185774
Encoded Proteins
Kv channel interacting protein 4
Kv channel interacting protein 4
Kv channel interacting protein 4
Kv channel interacting protein 4
Kv channel interacting protein 4
Kv channel interacting protein 4
Kv channel interacting protein 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belong to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. This protein member also interacts with presenilin. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:20728616-21948799
Strand Reverse strand
Band p15.2
Transcripts
ENST00000382152 ENSP00000371587
ENST00000382150 ENSP00000371585
ENST00000359001 ENSP00000351892
ENST00000382149
ENST00000382148 ENSP00000371583
ENST00000447367 ENSP00000399080
ENST00000509207 ENSP00000423257
ENST00000515786 ENSP00000445321
ENST00000515373
ENST00000512102
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005244 voltage-gated ion channel activity
GO:0005267 potassium channel activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
Biological Process
GO:0007165 signal transduction
GO:0034765 regulation of ion transmembrane transport
GO:0045087 innate immune response
GO:0071805 potassium ion transmembrane transport
Cellular Component
GO:0005578 proteinaceous extracellular matrix
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0030425 dendrite
GO:0043025 neuronal cell body
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
Regulation of nuclear beta catenin signaling and target gene transcription
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.705981
RefSeq NM_001035003 NM_001035004 NM_025221 NM_147181 NM_147182 NM_147183 XM_005248190
HUGO
OMIM
CCDS CCDS3428 CCDS43215 CCDS43216 CCDS43217 CCDS47035
HPRD 12184
IMGT
EMBL
GenPept
RNA Seq Atlas