InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MED10

Summary

InnateDB Protein

IDBP-11558.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MED10

Protein Name

mediator complex subunit 10

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000255764

InnateDB Gene

IDBG-11556 (MED10)

Protein Structure

UniProt Annotation

Function

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 70 experimentally validated interaction(s) in this database.

Experimentally validated
Total	70 [view]
Protein-Protein	69 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001104	RNA polymerase II transcription cofactor activity

Biological Process

GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0010467	gene expression
GO:0019827	stem cell maintenance
GO:0045944	positive regulation of transcription from RNA polymerase II promoter