InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: MED10

Summary

InnateDB Gene

IDBG-11556.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MED10

Gene Name

mediator complex subunit 10

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000133398

Encoded Proteins

IDBP-11558

mediator complex subunit 10

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

MED10 is a component of the Mediator complex, which is a coactivator for DNA-binding factors that activate transcription via RNA polymerase II (Sato et al., 2003 [PubMed 12584197]).[supplied by OMIM, Oct 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:6371881-6378594

Strand

Reverse strand

Band

p15.31

Transcripts

ENST00000255764	ENSP00000255764
ENST00000503112
ENST00000504058

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 70 experimentally validated interaction(s) in this database.

Experimentally validated
Total	70 [view]
Protein-Protein	69 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001104	RNA polymerase II transcription cofactor activity

Biological Process

GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0010467	gene expression
GO:0019827	stem cell maintenance
GO:0045944	positive regulation of transcription from RNA polymerase II promoter