InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SLC27A2

Summary

InnateDB Protein

IDBP-11581.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC27A2

Protein Name

solute carrier family 27 (fatty acid transporter), member 2

Synonyms

ACSVL1; FACVL1; FATP2; hFACVL1; HsT17226; VLACS; VLCS;

Species

Homo sapiens

Ensembl Protein

ENSP00000370289

InnateDB Gene

IDBG-11577 (SLC27A2)

Protein Structure

UniProt Annotation

Function

Acyl-CoA synthetase probably involved in bile acid metabolism. Proposed to activate C27 precurors of bile acids to their CoA thioesters derivatives before side chain cleavage via peroxisomal beta-oxidation occurs. In vitro, activates 3-alpha,7- alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol. Does not utilize C24 bile acids as substrates. In vitro, also activates long- and branched-chain fatty acids and may have additional roles in fatty acid metabolism. May be involved in translocation of long-chain fatty acids (LFCA) across membranes (By similarity). {ECO:0000250}.

Subcellular Localization

Endoplasmic reticulum membrane; Multi-pass membrane protein. Peroxisome membrane; Multi-pass membrane protein. Note=Peripheral membrane associated with the lumenal side of peroxisomes.

Disease Associations

Tissue Specificity

Expressed in liver, kidney, placenta and pancreas. {ECO:0000269PubMed:10198260}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004467	long-chain fatty acid-CoA ligase activity
GO:0005102	receptor binding
GO:0005524	ATP binding
GO:0019899	enzyme binding
GO:0031957	very long-chain fatty acid-CoA ligase activity
GO:0050197	phytanate-CoA ligase activity
GO:0070251	pristanate-CoA ligase activity

Biological Process

GO:0001561	fatty acid alpha-oxidation
GO:0001676	long-chain fatty acid metabolic process
GO:0006635	fatty acid beta-oxidation
GO:0006699	bile acid biosynthetic process
GO:0008152	metabolic process
GO:0008206	bile acid metabolic process
GO:0044255	cellular lipid metabolic process
GO:0044281	small molecule metabolic process
GO:0044539	long-chain fatty acid import
GO:0097089	methyl-branched fatty acid metabolic process

Cellular Component

GO:0005778	peroxisomal membrane
GO:0005779	integral component of peroxisomal membrane
GO:0005788	endoplasmic reticulum lumen
GO:0005789	endoplasmic reticulum membrane
GO:0030176	integral component of endoplasmic reticulum membrane
GO:0070062	extracellular vesicular exosome