Version 5.4
Homo sapiens Gene: SLC27A2
Summary
InnateDB Gene IDBG-11577.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC27A2
Gene Name solute carrier family 27 (fatty acid transporter), member 2
Synonyms ACSVL1; FACVL1; FATP2; hFACVL1; HsT17226; VLACS; VLCS
Species Homo sapiens
Ensembl Gene ENSG00000140284
Encoded Proteins
IDBP-11579
solute carrier family 27 (fatty acid transporter), member 2
IDBP-11581
solute carrier family 27 (fatty acid transporter), member 2
IDBP-584300
solute carrier family 27 (fatty acid transporter), member 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is an isozyme of long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme activates long-chain, branched-chain and very-long-chain fatty acids containing 22 or more carbons to their CoA derivatives. It is expressed primarily in liver and kidney, and is present in both endoplasmic reticulum and peroxisomes, but not in mitochondria. Its decreased peroxisomal enzyme activity is in part responsible for the biochemical pathology in X-linked adrenoleukodystrophy. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:50182196-50236395
Strand Forward strand
Band q21.2
Transcripts
ENST00000267842 ENSP00000267842
ENST00000380902 ENSP00000370289
ENST00000544960 ENSP00000444549
ENST00000559938
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004467 long-chain fatty acid-CoA ligase activity
GO:0005102 receptor binding
GO:0005524 ATP binding
GO:0015245 fatty acid transporter activity
GO:0019899 enzyme binding
GO:0031957 very long-chain fatty acid-CoA ligase activity
GO:0050197 phytanate-CoA ligase activity
GO:0070251 pristanate-CoA ligase activity
Biological Process
GO:0000038 very long-chain fatty acid metabolic process
GO:0001561 fatty acid alpha-oxidation
GO:0001676 long-chain fatty acid metabolic process
GO:0006635 fatty acid beta-oxidation
GO:0006699 bile acid biosynthetic process
GO:0008152 metabolic process
GO:0008206 bile acid metabolic process
GO:0015908 fatty acid transport
GO:0042760 very long-chain fatty acid catabolic process
GO:0044255 cellular lipid metabolic process
GO:0044281 small molecule metabolic process
GO:0044539 long-chain fatty acid import
GO:0097089 methyl-branched fatty acid metabolic process
Cellular Component
GO:0005739 mitochondrion
GO:0005777 peroxisome
GO:0005778 peroxisomal membrane
GO:0005779 integral component of peroxisomal membrane
GO:0005783 endoplasmic reticulum
GO:0005788 endoplasmic reticulum lumen
GO:0005789 endoplasmic reticulum membrane
GO:0030176 integral component of endoplasmic reticulum membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000027359
View Gene Order
ENSBTAG00000004303
Not yet available
Pathways
NETPATH
REACTOME
REACT_17003
Alpha-oxidation of phytanate pathway
REACT_11053
Synthesis of bile acids and bile salts via 24-hydroxycholesterol pathway
REACT_11041
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol pathway
REACT_11054
Synthesis of bile acids and bile salts pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_16957
Peroxisomal lipid metabolism pathway
REACT_11040
Bile acid and bile salt metabolism pathway
REACT_111217
Metabolism pathway
KEGG
hsa03320
PPAR signaling pathway pathway
hsa04146
Peroxisome pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL G3V1R7
UniProt Splice Variant
Entrez Gene 11001
UniGene Hs.11729
RefSeq NM_001159629 NM_003645
HUGO HGNC:10996
OMIM 603247
CCDS CCDS10133 CCDS53943
HPRD 11935
IMGT
EMBL AC009753 CH471082
GenPept EAW77385
RNA Seq Atlas 11001

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca