InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HDC

Summary

InnateDB Protein

IDBP-11606.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HDC

Protein Name

histidine decarboxylase

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000267845

InnateDB Gene

IDBG-11604 (HDC)

Protein Structure

UniProt Annotation

Function

Catalyzes the biosynthesis of histamine from histidine. {ECO:0000269PubMed:22767596}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004398	histidine decarboxylase activity
GO:0016831	carboxy-lyase activity
GO:0030170	pyridoxal phosphate binding

Biological Process

GO:0001694	histamine biosynthetic process
GO:0006547	histidine metabolic process
GO:0006548	histidine catabolic process
GO:0019752	carboxylic acid metabolic process
GO:0034641	cellular nitrogen compound metabolic process
GO:0042423	catecholamine biosynthetic process
GO:0044281	small molecule metabolic process

Cellular Component

GO:0005829

cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR002129 Pyridoxal phosphate-dependent decarboxylase
IPR010977 Aromatic-L-amino-acid decarboxylase
IPR015424 Pyridoxal phosphate-dependent transferase

PFAM

PF00282

PRINTS

PR00800

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P19113