Version 5.4
Homo sapiens Gene: HDC
Summary
InnateDB Gene IDBG-11604.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HDC
Gene Name histidine decarboxylase
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000140287
Encoded Proteins
IDBP-11606
histidine decarboxylase
IDBP-598499
histidine decarboxylase
IDBP-592976
histidine decarboxylase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the group II decarboxylase family and forms a homodimer that converts L-histidine to histamine in a pyridoxal phosphate dependent manner. Histamine regulates several physiologic processes, including neurotransmission, gastric acid secretion,inflamation, and smooth muscle tone.[provided by RefSeq, Aug 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:50241947-50266026
Strand Reverse strand
Band q21.2
Transcripts
ENST00000267845 ENSP00000267845
ENST00000559816
ENST00000543581 ENSP00000440252
ENST00000558761
ENST00000559190
ENST00000558679
ENST00000559683 ENSP00000453183
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004398 histidine decarboxylase activity
GO:0016831 carboxy-lyase activity
GO:0030170 pyridoxal phosphate binding
Biological Process
GO:0001694 histamine biosynthetic process
GO:0006520 cellular amino acid metabolic process
GO:0006547 histidine metabolic process
GO:0006548 histidine catabolic process
GO:0019752 carboxylic acid metabolic process
GO:0034641 cellular nitrogen compound metabolic process
GO:0042423 catecholamine biosynthetic process
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000027360
View Gene Order
ENSBTAG00000009911
Not yet available
Pathways
NETPATH
REACTOME
REACT_1249
Histidine catabolism pathway
REACT_13
Metabolism of amino acids and derivatives pathway
REACT_111217
Metabolism pathway
KEGG
hsa00340
Histidine metabolism pathway
INOH
INOH website
Histidine degradation pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.1481
RefSeq NM_002112
HUGO
OMIM
CCDS CCDS10134
HPRD 00817
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca