InnateDB Protein
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IDBP-11698.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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PAPD7
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Protein Name
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PAP associated domain containing 7
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Synonyms
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LAK-1; LAK1; POLK; POLS; TRF4; TRF4-1; TRF41; TUTASE5;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000230859
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InnateDB Gene
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IDBG-11696 (PAPD7)
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Protein Structure
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Function |
Catalytic subunit of a TRAMP-like complex which has a poly(A) RNA polymerase activity and is involved in a post- transcriptional quality control mechanism. Polyadenylation with short oligo(A) tails is required for the degradative activity of the exosome on several of its nuclear RNA substrates. Has no terminal uridylyltransferase activity, and does not play a role in replication-dependent histone mRNA degradation via uridylation. {ECO:0000269PubMed:23376078}.
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Subcellular Localization |
Cytoplasm {ECO:0000269PubMed:23376078}. Nucleus, nucleoplasm {ECO:0000269PubMed:23376078}. Note=Excluded from nucleolus, weak staining detected in the cytoplasm.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
4
[view]
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Protein-Protein |
2
[view]
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Protein-DNA |
2
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR002058
PAP/25A-associated
IPR002934
Nucleotidyl transferase domain
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PFAM |
PF03828
PF01909
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q5XG87
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PhosphoSite |
PhosphoSite-Q5XG87
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TrEMBL |
D6RJD0
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UniProt Splice Variant |
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Entrez Gene |
11044
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UniGene |
Hs.481542
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RefSeq |
NP_008930
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HUGO |
HGNC:16705
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OMIM |
605198
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CCDS |
CCDS3871
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HPRD |
09239
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IMGT |
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EMBL |
AB005754
AC122710
AF089896
AK289857
AK303516
AY623114
BC084567
BC117137
BC126106
BC143882
CH471102
KC424495
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GenPept |
AAD45198
AAH84567
AAI17138
AAI26107
AAI43883
AAT38110
AGE92663
BAA24434
BAF82546
BAG64545
EAX08101
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