InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ENTPD5

Summary

InnateDB Protein

IDBP-11817.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ENTPD5

Protein Name

ectonucleoside triphosphate diphosphohydrolase 5

Synonyms

CD39L4; NTPDase-5; PCPH;

Species

Homo sapiens

Ensembl Protein

ENSP00000335246

InnateDB Gene

IDBG-11813 (ENTPD5)

Protein Structure

UniProt Annotation

Function

Uridine diphosphatase (UDPase) that promotes protein N- glycosylation and ATP level regulation. UDP hydrolysis promotes protein N-glycosylation and folding in the endoplasmic reticulum, as well as elevated ATP consumption in the cytosol via an ATP hydrolysis cycle. Together with CMPK1 and AK1, constitutes an ATP hydrolysis cycle that converts ATP to AMP and results in a compensatory increase in aerobic glycolysis. The nucleotide hydrolyzing preference is GDP > IDP > UDP, but not any other nucleoside di-, mono- or triphosphates, nor thiamine pyrophosphate. Plays a key role in the AKT1-PTEN signaling pathway by promoting glycolysis in proliferating cells in response to phosphoinositide 3-kinase (PI3K) signaling. {ECO:0000269PubMed:10400613}.

Subcellular Localization

Endoplasmic reticulum {ECO:0000250}. Secreted {ECO:0000269PubMed:10400613}.

Disease Associations

Tissue Specificity

Expressed in adult liver, kidney, prostate, testis and colon. Much weaker expression in other tissues. {ECO:0000269PubMed:9676430}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004382	guanosine-diphosphatase activity
GO:0016787	hydrolase activity
GO:0045134	uridine-diphosphatase activity

Biological Process

GO:0006487	protein N-linked glycosylation
GO:0008283	cell proliferation
GO:0014066	regulation of phosphatidylinositol 3-kinase signaling
GO:0016049	cell growth
GO:0045821	positive regulation of glycolytic process
GO:0046034	ATP metabolic process
GO:0051084	'de novo' posttranslational protein folding