Version 5.4
Homo sapiens Gene: ENTPD5
Summary
InnateDB Gene IDBG-11813.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ENTPD5
Gene Name ectonucleoside triphosphate diphosphohydrolase 5
Synonyms CD39L4; NTPDase-5; PCPH
Species Homo sapiens
Ensembl Gene ENSG00000187097
Encoded Proteins
IDBP-11817
ectonucleoside triphosphate diphosphohydrolase 5
IDBP-599958
ectonucleoside triphosphate diphosphohydrolase 5
IDBP-585363
ectonucleoside triphosphate diphosphohydrolase 5
IDBP-593564
ectonucleoside triphosphate diphosphohydrolase 5
IDBP-590244
ectonucleoside triphosphate diphosphohydrolase 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is similar to E-type nucleotidases (NTPases)/ecto-ATPase/apyrases. NTPases, such as CD39, mediate catabolism of extracellular nucleotides. ENTPD5 contains 4 apyrase-conserved regions which is characteristic of NTPases. [provided by RefSeq, Jan 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:73958010-74019399
Strand Reverse strand
Band q24.3
Transcripts
ENST00000334696 ENSP00000335246
ENST00000557325 ENSP00000451810
ENST00000555829 ENSP00000451499
ENST00000553284 ENSP00000451591
ENST00000556242 ENSP00000451483
ENST00000554664
ENST00000556108
ENST00000557681
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004382 guanosine-diphosphatase activity
GO:0016787 hydrolase activity
GO:0045134 uridine-diphosphatase activity
Biological Process
GO:0006487 protein N-linked glycosylation
GO:0008152 metabolic process
GO:0008283 cell proliferation
GO:0014066 regulation of phosphatidylinositol 3-kinase signaling
GO:0016049 cell growth
GO:0045821 positive regulation of glycolytic process
GO:0046034 ATP metabolic process
GO:0051084 'de novo' posttranslational protein folding
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000021236
View Gene Order
ENSBTAG00000020334
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa00240
Pyrimidine metabolism pathway
hsa00230
Purine metabolism pathway
INOH
INOH website
Purine nucleotides nucleosides metabolism pathway
INOH website
Pyrimidine nucleotides nucleosides metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.655070 Hs.656955 Hs.666702 Hs.669116 Hs.720540 Hs.734486
RefSeq NM_001249 XM_005268221 XM_005268222 XM_005268224 XM_006720324 XM_006720325
HUGO
OMIM
CCDS CCDS9825
HPRD 16015
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca