InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DHX15

Summary

InnateDB Protein

IDBP-11835.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DHX15

Protein Name

DEAH (Asp-Glu-Ala-His) box polypeptide 15

Synonyms

DBP1; DDX15; HRH2; PRP43; PRPF43; PrPp43p;

Species

Homo sapiens

Ensembl Protein

ENSP00000336741

InnateDB Gene

IDBG-11833 (DHX15)

Protein Structure

UniProt Annotation

Function

Pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA. In cooperation with TFIP11 seem to be involved in the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. {ECO:0000269PubMed:19103666}.

Subcellular Localization

Nucleus. Nucleus, nucleolus.

Disease Associations

Tissue Specificity

Ubiquitous.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 153 experimentally validated interaction(s) in this database.

Experimentally validated
Total	153 [view]
Protein-Protein	153 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003724	RNA helicase activity
GO:0003725	double-stranded RNA binding
GO:0004386	helicase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008026	ATP-dependent helicase activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006200	ATP catabolic process
GO:0006397	mRNA processing
GO:0008380	RNA splicing

Cellular Component

GO:0005634	nucleus
GO:0005689	U12-type spliceosomal complex
GO:0005730	nucleolus
GO:0071008	U2-type post-mRNA release spliceosomal complex

Protein Structure and Domains

PDB ID

InterPro

IPR001650 Helicase, C-terminal
IPR007502 Helicase-associated domain
IPR011545 DEAD/DEAH box helicase domain
IPR011709 Domain of unknown function DUF1605
IPR014001 Helicase, superfamily 1/2, ATP-binding domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00271
PF04408
PF00270
PF07717

PRINTS

PIRSF

SMART

SM00490
SM00847
SM00487

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O43143