InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PRODH

Summary

InnateDB Protein

IDBP-1201.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PRODH

Protein Name

proline dehydrogenase (oxidase) 1

Synonyms

HSPOX2; PIG6; POX; PRODH1; PRODH2; TP53I6;

Species

Homo sapiens

Ensembl Protein

ENSP00000349577

InnateDB Gene

IDBG-1197 (PRODH)

Protein Structure

UniProt Annotation

Function

Converts proline to delta-1-pyrroline-5-carboxylate.

Subcellular Localization

Mitochondrion matrix.

Disease Associations

Hyperprolinemia 1 (HP-1) [MIM:239500]: Characterized by elevated serum proline levels. May be involved in the psychiatric and behavioral phenotypes associated with the 22q11 velocardiofacial and DiGeorge syndrome. {ECO:0000269PubMed:12217952}. Note=The disease is caused by mutations affecting the gene represented in this entry.Schizophrenia 4 (SCZD4) [MIM:600850]: A complex, multifactorial psychotic disorder or group of disorders characterized by disturbances in the form and content of thought (e.g. delusions, hallucinations), in mood (e.g. inappropriate affect), in sense of self and relationship to the external world (e.g. loss of ego boundaries, withdrawal), and in behavior (e.g bizarre or apparently purposeless behavior). Although it affects emotions, it is distinguished from mood disorders in which such disturbances are primary. Similarly, there may be mild impairment of cognitive function, and it is distinguished from the dementias in which disturbed cognitive function is considered primary. Some patients manifest schizophrenic as well as bipolar disorder symptoms and are often given the diagnosis of schizoaffective disorder. {ECO:0000269PubMed:11891283}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Tissue Specificity

Expressed in lung, skeletal muscle and brain, to a lesser extent in heart and kidney, and weakly in liver, placenta and pancreas.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004657	proline dehydrogenase activity
GO:0071949	FAD binding

Biological Process

GO:0006537	glutamate biosynthetic process
GO:0006560	proline metabolic process
GO:0006562	proline catabolic process
GO:0008631	intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0010133	proline catabolic process to glutamate
GO:0019470	4-hydroxyproline catabolic process
GO:0034641	cellular nitrogen compound metabolic process
GO:0044281	small molecule metabolic process
GO:0055114	oxidation-reduction process