Version 5.4
Homo sapiens Protein: SEPSECS
Summary
InnateDB Protein IDBP-12105.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SEPSECS
Protein Name Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000371535
InnateDB Gene IDBG-12103 (SEPSECS)
Protein Structure
UniProt Annotation
Function Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl- tRNA(Sec) required for selenoprotein biosynthesis. {ECO:0000269PubMed:17142313}.
Subcellular Localization Cytoplasm.
Disease Associations Pontocerebellar hypoplasia 2D (PCH2D) [MIM:613811]: A disorder characterized by postnatal onset of progressive atrophy of the cerebrum and cerebellum, microcephaly, profound mental retardation, spasticity, and variable seizures. {ECO:0000269PubMed:20920667}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Tissue Specificity Primarily expressed in liver, pancreas, kidney and lung. Overexpressed in PHA-stimulated T-cells.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000049 tRNA binding
GO:0005515 protein binding
GO:0016740 transferase activity
GO:0016785 transferase activity, transferring selenium-containing groups
GO:0030170 pyridoxal phosphate binding
Biological Process
GO:0001514 selenocysteine incorporation
GO:0097056 selenocysteinyl-tRNA(Sec) biosynthetic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR008829 Soluble liver antigen/liver pancreas antigen
IPR015424 Pyridoxal phosphate-dependent transferase
IPR019872 O-phosphoseryl-tRNA(Sec) selenium transferase
PFAM PF05889
PRINTS
PIRSF PIRSF017689
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9HD40
PhosphoSite PhosphoSite-Q9HD40
TrEMBL A1A4F3
UniProt Splice Variant
Entrez Gene 51091
UniGene Hs.253305
RefSeq NP_058651
HUGO HGNC:30605
OMIM 613009
CCDS CCDS3432
HPRD 11561
IMGT
EMBL AC007073 AC104662 AF146396 AF282065 AJ238617 AJ277541 AK292476 BC023539 BC117202 BC126213 BX648976 CH471069
GenPept AAD33963 AAG00491 AAH23539 AAI17203 AAI26214 BAF85165 CAB62209 CAB89517 EAW92831 EAW92832 EAW92835

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca