InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CERK

Summary

InnateDB Protein

IDBP-12221.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CERK

Protein Name

ceramide kinase

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000216264

InnateDB Gene

IDBG-12219 (CERK)

Protein Structure

UniProt Annotation

Function

Catalyzes specifically the phosphorylation of ceramide to form ceramide 1-phosphate. Acts efficiently on natural and analog ceramides (C6, C8, C16 ceramides, and C8-dihydroceramide), to a lesser extent on C2-ceramide and C6-dihydroceramide, but not on other lipids, such as various sphingosines. Binds phosphoinositides. {ECO:0000269PubMed:19168031}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:19168031}. Membrane {ECO:0000269PubMed:19168031}; Peripheral membrane protein {ECO:0000269PubMed:19168031}.

Disease Associations

Tissue Specificity

High level expression in heart, brain, skeletal muscle, kidney and liver; moderate in peripheral blood leukocytes and thymus; very low in spleen, small intestine, placenta and lung.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0001729	ceramide kinase activity
GO:0003951	NAD+ kinase activity
GO:0004143	diacylglycerol kinase activity
GO:0005524	ATP binding

Biological Process

GO:0006665	sphingolipid metabolic process
GO:0006672	ceramide metabolic process
GO:0006687	glycosphingolipid metabolic process
GO:0007205	protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0008152	metabolic process
GO:0016310	phosphorylation
GO:0044281	small molecule metabolic process
GO:0046834	lipid phosphorylation