Version 5.4
Homo sapiens Gene: CERK
Summary
InnateDB Gene IDBG-12219.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CERK
Gene Name ceramide kinase
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000100422
Encoded Proteins
IDBP-12221
ceramide kinase
IDBP-380317
ceramide kinase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary CERK converts ceramide to ceramide 1-phosphate (C1P), a sphingolipid metabolite. Both CERK and C1P have been implicated in various cellular processes, including proliferation, apoptosis, phagocytosis, and inflammation (Kim et al., 2006 [PubMed 16488390]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:46684411-46738261
Strand Reverse strand
Band q13.31
Transcripts
ENST00000216264 ENSP00000216264
ENST00000443629 ENSP00000400859
ENST00000471929
ENST00000460254
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000287 magnesium ion binding
GO:0001729 ceramide kinase activity
GO:0003951 NAD+ kinase activity
GO:0004143 diacylglycerol kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006665 sphingolipid metabolic process
GO:0006672 ceramide metabolic process
GO:0006687 glycosphingolipid metabolic process
GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0008152 metabolic process
GO:0016310 phosphorylation
GO:0044281 small molecule metabolic process
GO:0046834 lipid phosphorylation
Cellular Component
GO:0005739 mitochondrion
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000035891
View Gene Order
ENSBTAG00000046654
Not yet available
Pathways
NETPATH
REACTOME
REACT_116105
Glycosphingolipid metabolism pathway
REACT_19323
Sphingolipid metabolism pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_267716
Orphan transporters pathway
REACT_111217
Metabolism pathway
KEGG
hsa00600
Sphingolipid metabolism pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.200668
RefSeq NM_022766
HUGO
OMIM
CCDS CCDS14077
HPRD 09878
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca